Metaplastic carcinoma breast

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We are presenting a case of a year-old female with a fungating, ulceroproliferative mass involving her whole breast including the nipple areola complex which turns out to be a rare form metaplastic breast carcinoma with extensive squamous differentiation. Tavassoli FA. Classification of metaplastic carcinomas of the breast.

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Seven cases of MBC were evaluated for clinico-pathological features including follow up data. Three cases showed choriocarcinomatous features. P53 was positive in 3 cases, ki was strongly expressed in only one case, while calretinin was expressed in 6 cases.

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Follow us:. Metaplastic Carcinoma. In metaplastic carcinomas, the predominant cell type is other than epithelialusually a mesenchymal element.

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Subscribe to our What's New in Pathology newsletter - current issue on Hematopathology out now. Page views in 10, Cite this page: Roychowdhury M Metaplastic carcinoma - general. Accessed September 13th,

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Metaplastic carcinomas of breast are uncommon, representing 0. We are reporting two cases of metaplastic carcinoma breast, one revealing rhabdomyoblastic and spindle cell differentiation and other revealing osteoclast like giant cells. Both were estrogen receptor, progesterone receptor and Her2u negative on immunohistochemistry.

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Correspondence Address : Dr. Carcinosarcoma CS also known as metaplastic carcinoma of the breast is a rare and aggressive type of malignancy with controversial origin. Currently, there are no standard treatment guidelines outlined, owing to the rarity of the disease, but according to the available literature, surgery followed by adjuvant radiation therapy has the greatest benefit.

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Metaplastic breast cancer metaplastic carcinoma of the breast is a very uncommon type of breast cancer. It is a form of invasive ductal cancermeaning that it forms in the milk ducts and then moves into other tissues of the breast. It can be aggressive and fast-growing, and relatively little is known about metaplastic breast cancer's causes or long-term prognosis.

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Metaplastic breast cancer MBC is a malignancy characterized by the histologic presence of two or more cellular types, commonly a mixture of epithelial and mesenchymal components. Due to its low incidence and pathological variability, the ideal treatment paradigm for MBC is unknown. Despite similar treatment regimens, however, patients with MBC have worse outcomes. Recent research is focused on biological differences between MBC and IDC and potential novel targets for chemotherapeutic agents.

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Metaplastic carcinomaotherwise known as metaplastic carcinoma of the breast MCBis a heterogeneous group of cancers that exhibit varied patterns of metaplasia and differentiation along multiple cell lines. IDCand shares similar treatment approaches. MCB tumors are typically estrogen receptor ERprogesterone receptor PRand human epidermal growth factor-2 HER-2 negative, meaning hormone therapy is generally not an effective treatment option, which correlates to a relatively poor prognosis.

It differs from the more common kinds of breast cancer in both its makeup and in the way it behaves. Like invasive ductal cancer, metaplastic breast cancer begins in the milk duct of the breast before spreading to the tissue around the duct. What makes a metaplastic tumor different is the kinds of cells that make up the tumor.

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