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This is an open access article distributed under the terms of Creative Commons Attribution License. Hypoxia is an established characteristic of high-grade breast tumors 1 and is considered to be associated with increased therapy resistance, poor disease-free survival DFS and a high rate of metastasis 2 — 6. The hypoxia-inducible factor family members are key elements in the hypoxic signaling pathway 7. Intratumoral hypoxia is caused by abnormal microvasculature in proliferating tumor tissues, and may induce proteomic changes, allowing tumors to adapt to or overcome the nutrient-deprived state 8 —

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